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MK801 significantly decreased isoflurane MAC by 0 72 of an atmosphere in controls versus 0.. Solt Forman 2007 ), the effects of anesthetics on many cellular channels and receptors in the CNS are known.. However, isoflurane modulates GABA A receptors more potently than NMDA receptors.. In this study, spinal administration of picrotoxin was used to increase isoflurane MAC in rats, using immobility in response to a noxious stimulus as an endpoint ( Eger et al.. Keywords: intrathecal, isoflurane, minimum alveolar concentration, rat Introduction Although the mechanism of action of inhaled anesthetics remains a mystery ( Sonner et al. Project opensky crj 700 aircraft
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MK801 significantly decreased isoflurane MAC by 0 72 of an atmosphere in controls versus 0.. Solt Forman 2007 ), the effects of anesthetics on many cellular channels and receptors in the CNS are known.. However, isoflurane modulates GABA A receptors more potently than NMDA receptors.. In this study, spinal administration of picrotoxin was used to increase isoflurane MAC in rats, using immobility in response to a noxious stimulus as an endpoint ( Eger et al.. Keywords: intrathecal, isoflurane, minimum alveolar concentration, rat Introduction Although the mechanism of action of inhaled anesthetics remains a mystery ( Sonner et al. 773a7aa168 Project opensky crj 700 aircraft
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47 of an atmosphere in rats receiving intrathecal picrotoxin Conclusions and clinical relevance A smaller MK801 MAC-sparing effect in the picrotoxin group is consistent with greater NMDA antagonism by isoflurane in these animals, since it suggests that fewer NMDA receptors are available upon which MK801 could act to decrease isoflurane MAC.. Decreasing isoflurane GABA A potentiation increases isoflurane NMDA antagonism at MAC.. Increasing inhibitory GABA A chloride currents and decreasing excitatory NMDA cation currents both cause neuronal hyperpolarization that reduces cell excitability and likely contributes to the immobilizing ( Stabernack et al.. Animals Fourteen 10-week-old male SpragueDawley rats weighing 269 12 g Methods Indwelling lumbar subarachnoid catheters were surgically placed in isoflurane-anesthetized rats. Download Facebook Lite For Windows Phone 7